Tex Richman est un homme d'affaire qui compte acheter le théâtre des Muppets. Gary, Marie et Walter la marionnette se mettent alors à la recherche des anciens du théâtre, séparés depuis plusieurs années, afin de tenter de sauver cet endroit qui leur est très cher. Ils arrivent à retrouver Kermit la grenouille qui part à son tour dans le but de réunir ses anciens compagnons de scène.
The Muppet Show Theme — The Muppets & Joanna Newsom
Rainbow Connection avec Kermit la grenouille
"Muppet Studios, I Can't Believe It" — Walter
Life's a Happy Song (From "The Muppets") — Mickey Rooney & Feist & Amy Adams & Jason Segel & Walter
"I Haven't Seen the Old Gang" — Jason Segel & Kermit
Pictures In My Head — Gonzo & Fozzie & Swedish Chef & Kermit & Dr. Teeth and the Electric Mayhem
"We Drive" — Walter & Kermit
Me and Julio Down By the Schoolyard — Paul Simon
"That Spells Reno" — Amy Adams & 80's Robot
Rainbow Connection (Moopets Version) — The Moopets
"Welcome Back" — Fozzie & Walter & Kermit & Dr. Teeth
We Built This City — Starship
"Party of One" — Amy Adams & Sarah Silverman
Me Party — Miss Piggy & Amy Adams
"We Humbly Ask" — Kermit & Chris Cooper
Let's Talk About Me — Nathan Pacheco & Chris Cooper
"The Answer Is No" — Kermit & Chris Cooper
"Are You a Man Or a Muppet?" — Amy Adams
Man Or Muppet — Jason Segel & Walter
"Down At the Ole Barbershop" — Kermit
Smells Like Teen Spirit — The Muppets Barbershop Quartet
"Princesses of Poultry" — Kermit
Forget You — Camilla and the Chickens
"It's Time For Our Song" — Miss Piggy & Kermit
Rainbow Connection — The Muppets
"Get Out There and Help Those Guys" — Jason Segel
The Whistling Caruso — Andrew Bird
La performance de Walter au Muppet Show
"How Charming, A Finale" — Uncle Deadly
Life's a Happy Song Finale — The Muppets & Amy Adams & Andrew Walter & Jason Segel & Chris Cooper
"Mary, Marry Me" — Amy Adams & Jason Segel
Mah Na Mah Na — Mahna Mahna and The Two Snowths
Bad to the Bone — George Thorogood & The Destroyers
Cars — Gary Numan
Kermit initie le roadtrip pour rassembler le reste des muppets.
(I've Had) The Time of My Life — Bill Medley & Jennifer Warnes